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March 1996, Volume 2 No. 1
ARTICLE 7
The effect of cellulose on
crystal formation in the kidneys of guinea pigs fed diet rich in
calcium and sodium
Syed Shamsuddin Syed
Hussain1, Tan Kah Ooi1 & Mohd Azman Abu Bakar2
1 Department of Biochemistry, Faculty of Medicine, &
2 Department of Biomedical Sciences, Faculty of Allied Health
Sciences, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur.
ABSTRACT
Our earlier report showed that diet rich in calcium and sodium
fed to guinea pigs can be urolithogenic. In this study, we
investigated the effect of adding 3% or 15% cellulose as a source of
fiber into similar diet to asses the formation of kidney calculus.
From the result, animals fed diet with 3% cellulose showed a
relatively high concentration of urinary oxalate, urate and large
number of crystals in the kidneys. When the cellulose level was
raised to 15%, the concentrations of urinary calcium, urate and the
number of crystals formed in the kidneys were lowered. We therefore,
conclude that high fiber diet may be beneficial in reducing the
incidence of kidney stones of calcium origin.
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