Mal J Nutr 21(1): 75 - 82, 2015

Effects of Oil Palm (Elaeis guineensis) Fruit Extracts on Insulin Secretion from BRIN BD11 Cells
Faez S1,2, Muhajir H2* Amin I3, & Zainah A4

ABSTRACT

Introduction: Diabetes is one of the top ten causes of mortality in Malaysia. Several antidiabetic studies using palm oil (Elaeis guineensis) have been explored in recent years. The oil palm fruit itself has not been investigated and hence this study was conducted to evaluate its effects in stimulating insulin secretion from pancreatic fl-cell.
Methods: The insulinotropic activity of oil palm fruit aqueous extract (OPF) on clonal pancreatic fl-cell line was investigated using BRIN BD11 cell line. The cell lines were incubated with different concentrations of OPF to evaluate the stimulatory effect of OPF toward insulin secretion from BRIN BD11 cells using the Rat Insulin ELISA Assay Kits.
Results: OPF concentrations (100-1000,ug/m1) were shown to significantly induce insulin secretion by a multiple of 1.97-2.58 in the BRIN BD11 cells. The highest insulin secretion increase (2.58-fold, p<0.001) was induced by 500 ,ug/m1 in the OPF treated group. Evaluation of the possible mechanisms involved suggested that the mechanisms of insulin secreting activity of the 500 ,ug/m1 OPF extract may involve the IC,m, channel-dependent pathway which exerts an insulin secretion effect through depolarising the membrane of pancreatic fl-cells.
Conclusion: The present study has revealed the presence of insulinotropic activity in Elaeis guineensis fruit. Future work assessing its use as a source of active components is recommended.

Keywords: Elaeis guineensis, hypoglycaemic, insulin, insulinotropic, oil palm fruit extract

Download full article

March 1995, Vol1 No.1
September 1995, Vol1 No.2
March 1996, Vol2 No.1
September 1996, Vol2 No.2
March 1997, Vol3 No.1
September 1997, Vol3 No.2
December 1998, Vol4 No.1&2
December 1999, Vol5 No.1&2
March 2000, Vol6 No.1
September 2000, Vol6 No.2
Mar/Sept 2001, Vol7 No.1&2
March 2002, Vol8, No.1
September 2002, Vol8, No.2
March 2003, Vol9 No.1
September 2003, Vol9 No.2
March 2004, Vol10 No.1
September 2004, Vol10 No. 2
2005, Vol 11 No.1
2005, Vo l11 No.2
2006, Vol 12 No.1
2006, Vol 12 No.2
2007, Vol 13 No.1
2007, Vol 13 No.2
March 2008, Vol 14 No.1
2008, Vol 14 No.2
2009, Vol 15 No.1
2009, Vol 15 No.2
2010, Vol 16(1)

2010, Vol 16(2)

2010, Vol 16(3)

2011, Vol 17(1)

2011, Vol 17(2)

2011, Vol 17(3)

2012, Vol 18(1)

2012, Vol 18(2)

2012, Vol 18(3)

2013, Vol 19(1)

2013, Vol 19(2)

2013, Vol 19(3)

2014, Vol 20(1)

2014, Vol 20(2)

2014, Vol 20(3)

2015, Vol 21(1)

2015, Vol 21(2)

2015, Vol 21(3)

2016, Vol 22(1)

2016, Vol 22(2)

2016, Vol 22 Supplement

2016, Vol 22(3)

2017, Vol 23(1)

2017, Vol 23(2)