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2007, Volume 13 No. 1
ARTICLE 8
Chemical Composition and Biological Activity of the
Centipeda minima (Asteraceae)
Surjani Soetardjo1, Jong Poh Chan1, Ahmad Mohamad
Noor2,
Yoga Latha Lachimanan3 & Sasidharan Sreenivasan3
1 School of Distance Education, 2 School of Chemical Sciences,
3 School of Biological Sciences,
Universiti Sains Malaysia, 11800 Minden, Pulau Pinang, Malaysia.
ABSTRACT
The antimicrobial activity of the Centipeda minima L. (Asteraceae) extract was
evaluated against seven microorganisms using the disc diffusion method. The
extract showed a broad spectrum of antimicrobial activity against all the
tested bacterial strains, especially Enterobacter aerogenes, Klebsiella pneumonia,
Staphylococcus aureus and Yersinia enterocolitica. The chemical composition of
the extract obtained from Centipeda minima was analysed by GC–MS. Twentythree
compounds, constituting about 84.75 % of the total extract, were identified.
The main constituents were palmitic acid (7.47%), (Z,Z)-9-,12-octadecatrienoic
acid (6.52%), (Z,Z,Z)-9-,12-octadecatrienoic acid (7.01%), phytol
(7.01%), naptho[2.3-b]furan-2-(3H)-on (6.21%), 1-(1,2,3,4,7,7a-hexahydro-1,4,4,5-tetramethyl-1,3a-ethano-3aH-inden-6-yl)etanon (7.95%), 1,3,5-tri-tertbutyl-
benzene (4.52%), (3Z)-2-methyl-3-octen-2-ol (5.95%) and artemisia
ketone (4.98%). The extract was also tested against brine shrimp for toxicity.
There was no significant toxicity as it only recorded a LC50 value of 4.92
mg/ml. The study shows that the extract is a good antimicrobial agent with
potential applications in public health against diseases.
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