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2005, Volume 11 No. 1
SHORT COMMUNICATION
Serum Micronutrient (a-tocopherol, retinol, copper, zinc)
Status of Immunosuppressed Rats
Sheikh Nazrul Islam1, Parveen Begum1 and Monira Ahsan2
1Institute of Nutrition and Food Science, 2Department of Pharmaceutical Chemistry, University
of Dhaka, Dhaka-1000, Bangladesh
ABSTRACT
Micronutrients are immuno-active and some of the nutraceuticals have
been reported to modify immune responses. An attempt was made to
investigate the immuno-suppression effects by a nutraceutical- volatile
oil of Nigella sativa (NSVO). To induce immuno-suppression, animals
were challenged with a specific antigen, and then treated with NSVO
intramuscularly for 30 days. Serum micronutrients (alpha-tocopherol,
retinol, copper and zinc) of immune-suppressed rats were determined.
The HPLC was employed to determine the serum concentrations of vitamin
E and A, and atomic absorption flame spectrophotometry was used
to estimate the concentrations of serum zinc and copper. The SPSS software
package (version 10.0) was used to analyse the data. It was found
that immuno-suppressed rats showed significant deceases in serum concentrations
of retinol (P=0.005) and zinc (P=0.003), when compared with
control rats. Serum concentrations of alpha-tocopherol and copper also
increased but not significantly. This study revealed that immune suppression
might bring about changes in the concentrations of certain
serum micronutrients.
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